S23

What is S23?

S23 is an orally available, selective androgen receptor modulator (SARM). This compound was originally developed by GTX Inc. as a male form of hormonal contraception. It has a high affinity for the androgen receptor, with a Ki value of 1.7 nM. A study published by Jones et al. compared the effectiveness of S23 in both castrated and intact male rats.

Effects on fertility

In castrated male rats, the effective dose of S23 in the prostate was 0.43 mg/day and in the levator ani muscle 0.079 mg/day. In intact male rats, a dose higher than 0.1 mg/day resulted in a suppression of luteinizing hormone (LH) by more than 50%. This dose corresponded to a reduction in prostate size and an increase in the size of the levator ani muscle.

In a study with intact male test animals that were treated with both S23 and estradiol benzoate (to maintain sexual behavior), after 10 weeks, no sperm was found in the testicles of four out of six test animals. Furthermore, no pregnancies were reported in any of the six test animals. After treatment, the infertility was completely reversible; all subsequent mating trials resulted in pregnancy.

Effects on muscle mass and body fat

S23 shows effects on muscle mass and body fat that are comparable to those of anabolic steroids. Research in male rats indicated that treatment with S23 led to a decrease in total body weight and fat mass. The rats in this study were also administered estradiol benzoate to maintain sexual behavior. Despite the known muscle loss due to estrogens, the combination with S23 neutralized this effect and resulted in an increase in muscle mass in the male rats.

"Additionally, another study showed that S23 can be effective against muscle loss caused by prolonged use of glucocorticoids. This research also looked at the effects of S23 on muscle atrophy caused by castration. In both scenarios, muscle loss was observed, but the administration of S23 and testosterone blocked the dexamethasone-induced dephosphorylation of Akt. The results suggest that S23 may be an effective treatment for glucocorticoid-induced muscle loss."

🧪 Contents

The jar contains 1 gram of pure S23 powder.
A measuring scoop is not included.
'For accurate weighing, we recommend using a precision scale.'

📄 Disclaimer

This material is sold exclusively for use in laboratory research. Sales conditions apply. Not for human consumption, nor for medical, veterinary, or household use. Familiarize yourself with our DISCLAIMER before ordering.