RAD-150 (TBL 150)

RAD 150, also known as TLB 150, is the esterified version of the popular RAD-140 sarm.
RAD-140 has been most thoroughly studied in male gonadectomized rats suffering from neurodegenerative decline due to decreased androgen levels.


Overall, the fascinating study conducted by Jayaramen et. Al concluded that RAD 140 supplementation had neuroprotective effects on the brain via MAPK signaling in male rats. In addition, the study found that treatment with RAD 140 was actually just as effective in protecting against cell death as treatment with testosterone (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/). In addition to providing neuroprotection, testing RAD 140 in young monkeys over a 28-day period was found to result in an average 10% increase in body weight. Through the use of DEXA scans, it was discovered that the weight gain was mainly lean muscle mass.


Process of esterification
Esterification occurs when a substitution reaction takes place. The specific substitution reaction that occurs when a compound becomes an ester is derived from a carboxylic acid. The hydroxyl group (-OH) of the carboxylic acid has been replaced by an alkyl group (-O-). Esterification occurs when the carboxylic acid is exposed to heat and a strong acid, normally sulfuric acid. In some cases, various other strong acids such as hydrochloric acid will be used to catalyze the substitution reaction (https://www.chemguide.co.uk/organicprops/alcohols/esterification.html).



Difference between RAD 140 and RAD 150
RAD 150 is the esterified version of RAD 140. The main structural difference between the two compounds is the group of benzoate esters that were added during the substitution reaction of esterification. Adding the group of benzoate esters increases the alkalinity of the compound, making it more stable than RAD 140. To synthesize RAD 150 from Testolone, it must undergo the process of esterification. During the substitution reaction, a group of benzoate esters is added to Testolone to change the compound into its esterified version, which explains the main structural difference between the two compounds. Due to the addition of the benzoate ester group, the compound now has an increased alkalinity, indicating that the esterified compound is more stable than testolone.



In addition, in a similar way to other esterified SARMs, the bioavailability and half-life of RAD 150 are increased. With increased bioavailability, the compound is absorbed much faster, and with an increased half-life, the compound is active for much longer than RAD 140, the non-esterified compound. This indicates that additional potential benefits are added by esterification of RAD 140. In addition, when Testolone is compared to RAD 150, RAD 150 is comparable to other esterified SARMs with an increase in half-life and bioavailability. By increasing the half-life of RAD 150, the compound is considered active for a longer period of time than with testosterone supplementation. In addition, when bioavailability is increased, the compound is absorbed more quickly. It can be concluded that when Testolone undergoes esterification, there are several additional benefits that can be derived from the resulting compound.

Concentration

20 mg / ml.

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Data sheet

RAD-150 (TBL 150) - Solution, 600mg (20mg/ml)