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Cardarine GW-501516
What is GW-501516?
GW-501516 is a PPAR agonist (Peroxisome Proliferator-Activated Receptor), originally developed by GlaxoSmithKline for the treatment of hyperlipidemia, obesity, metabolic dysfunction, and heart diseases. The compound is also known as Endurobol or Cardarine, and is often referred to in research as a PPARδ agonist.
Research shows that GW-501516 affects fatty acid metabolism, skeletal muscle endurance, and glucose-insulin balance. PPARδ also plays a role in mitochondrial respiration, inflammation regulation, muscle recovery, and keratinocyte differentiation (source).
Research on endurance and fat burning
In a mouse study, three weeks of GW-501516 administration led to a 31.2% increase in running speed in trained rats and 68.6% in untrained ones. After just one week, an improvement of 48.6% was already observed compared to the control group. The combination of Cardarine and physical training resulted in increased fatty acid oxidation and energy utilization from long-chain fatty acids (source).
The activation of PPARδ also influenced muscle reprogramming through gene expression for contractile proteins, mitochondrial biogenesis, and fat burning.
Effects on metabolic markers and inflammation
'In mice on a high-fat diet, GW-501516 led to reduced insulin resistance, increased mitochondrial activity, lower fat storage in muscles, and decreased glucose and insulin levels (source).'
"Another study in fructose-fed rats showed a decrease in liver inflammation and a reduction in lipogenic gene expression. At the same time, genes that stimulate fat burning were increased (source)."
Research in rhesus monkeys showed improvements in HDL, LDL, triglycerides, and insulin levels, making Cardarine a potential research subject for cardiovascular diseases and metabolic syndrome (source).
🧪 Contents
In the jar is 1 gram of pure GW-501516 powder.
A measuring scoop is not included.
'For accurate weighing, we recommend using a precision scale.'
📄 Disclaimer
This material is sold exclusively for use in laboratory research. Sales conditions apply. Not for human consumption, nor for medical, veterinary, or household use. Familiarize yourself with our DISCLAIMER before ordering.
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