- Description
- Data sheet
GW-0742
GW-0742 is a PPAR-β agonist/antagonist, with function dependent on dose. In addition, it shows weak activity at several nuclear receptors.
It is antagonistic towards androgen receptors and VDR (Vitamin D Receptors). In silico modeling suggests that GW-0742 may also affect thyroid hormone receptors.
Studies have shown that GW-0742 can improve experimentally induced pancreatitis in mice. In addition, it has been observed to prevent hypertension in mice that have become obese from their diet. It is also being researched as a potential antidiabetic agent and has anti-inflammatory properties.
Concentration
20 mg/ml
Disclaimer
This material is sold for use in laboratory research only. Specific sales conditions apply. It is not intended for human consumption, medical, veterinary or household use. Please read our disclaimer carefully before placing an order.
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Application |
Potent PPARβ and PPARδ agonist |
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CAS |
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molar massa |
471.5 g/mol |
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Chemical formula |
C 21 H 17 F 4 NEE 3 S 2 |
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IUPAC name |
2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid |
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Synonyms |
GW0742, 317318-84-6, GW 0742, GW-0742, GW0742X, GW610742, GW-0742X, CHEMBL38508, CHEBI:79991, {4-[({2-[3-Fluoro-4-(Trifluoromethyl)phenyl]- 4-Methyl-1,3-Thiazol-5-Yl}methyl)sulfanyl]-2-Methylphenoxy}acetic acid, SR-05000000447, 3tkm, GW 0742X, GWdelta 0742, GW 610742, GW-610742, DSSTox_CID_20760, DSSTox_RID_99591, DSSTox_91_RID_79591, DSSTox_RID_99591, DSSTox , MLS006011159 |
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Bulletin |
Store at room temperature, tightly closed, away from heat, light and moisture. |
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Solubility |
Soluble in DMSO, PEG 400 |
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Organoleptic profile |
Clear liquid |
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Physical form |
molding solution in PEG400 |
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Specification |
20mg/mL ±5% |
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Terms and conditions |
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary or household use. Please familiarize yourself with our DISCLAIMER before ordering. |
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